Indication
Adjunct to diet for the treatment of patients w/ elevated total cholesterol (total-C), LDL-C, apo B, & triglycerides (TG). Increase HDL-C in patients w/ primary hypercholesterolemia (heterozygous familial & nonfamilial hypercholesterolemia), combined (mixed) hyperlipidemia (Fredrickson types IIa & IIb), elevated serum TG levels (Fredrickson type IV), & for patients w/ dysbetalipoproteinemia (Fredrickson type III) who do not respond adequately to diet. Reduction of total-C & LDL-C in patients w/ HoFH. Reduce the risk of fatal CHD & non-fatal MI, stroke, revascularization procedures & angina pectoris in patients w/o clinically evident CV disease, & w/ or w/o dyslipidemia, but w/ multiple risk factors for CHD (eg, smoking, HTN, diabetes, low HDL-C, or a family history of early CHD). Reduce the risk of non-fatal MI, fatal & non-fatal stroke, revascularization procedures, hospitalization for CHF, & angina in patients w/ clinically evident CHD. Adjunct to lifestyle changes (eg, proper diet & exercise) to halt the progression of atherosclerosis (total atheroma or plaque vol) in patients w/ CAD & other individuals who are at high risk for CV disease. Reduce the risk for CV disease in patients w/ diabetes w/ moderately decreased eGFR. Reduce the risk of major CV events including stroke in patients w/ clinically evident CHD & CKD not requiring dialysis. Reduce the rate of GFR decline & progression of CKD in patients w/ clinically evident CHD &/or diabetes w/ microalbuminuria. Adjunct to diet to reduce total-C, LDL-C, & apo B levels in boys & post-menarchal girls 10-17 yr w/ heterozygous familial hypercholesterolemia if after an adequate trial of diet therapy the LDL-remains ≥190 mg/dL or LDL-C remains ≥160 mg/dL & there is +ve family history of premature CVD or ≥2 other CVD risk factors are present.
